Association between residential greenness and gut microbiota in Chinese adults. (May 2022)

• Record Type: Journal Article
• Authors: Wu, Kunpeng; Guo, Bing; Guo, Yuming; Han, Mingming; Xu, Huan; Luo, Ruocheng; Hong, Zehui; Zhang, Baochao; Dong, Ke; Wu, Jialong; Zhang, Ning; Chen, Gongbo; Li, Shanshan; Zuo, Haojiang; Pei, Xiaofang; Zhao, Xing
• Is Part Of: Environment international. Volume 163(2022)
• Publication Date: 2022-05
• Subjects: Residential greenness -- Gut microbiota composition -- Population-based cohort study -- Weighting; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2022.107216
• Languages: English
• ISSNs: 0160-4120

Abstract

Graphical abstract: Highlights: Residential greenness may benefit gut microbial composition and increase the α-diversity. Important gut taxonomic composition such as Firmicutes may be influenced by residential greenness. First population-based and epidemiological study investigating the relationship between residential greenness and gut microbial composition. Generalized propensity score weighting was used to control for potential confounding. Abstract: Background: A growing body of studies have reported the health benefits of greenness. However, less is known about the potential beneficial effects of residential greenness on gut microbiota, which is essential to human health. In this study, we aim to examine the association between residential greenness and gut microbiota in a population-based cohort study. Methods: We included 1758 participants based on the China Multi-Ethnic Cohort (CMEC) study and collected their stool samples for 16S sequencing to derive gut microbiota data. Residential greenness was estimated using the satellite-based data on enhanced vegetation index (EVI) and the normalized differential vegetation index (NDVI) in circular buffers of 250 m, 500 m, and 1000 m. The relationships between residential greenness levels and the composition of gut microbiota, measured by standardized α-diversity and taxonomic composition, were assessed using linear regression and Spearman correlation weighted by generalized propensity scores. Results: Higher greenness levels were significantly positively associated with standardized α-diversity. Per interquartile range (IQR) increase of EVI and NDVI in the circular buffer of 250 m were associated with the increments of 0.995(95% confidence interval (CI): 0.212–1.778) and 0.653(95% CI: 0.160–1.146) in the standardized Shannon index. For the taxonomic composition of gut microbiota, higher greenness levels were significantly correlated with 29 types of microbial taxonomic composition. NDVI in the circular buffer of 250 m was associated with increased Firmicutes (r = 0.102, adjusted p value = 0.004), which was the dominant composition in the gut microbiota. Conclusions: Increased amounts of residential greenness may support healthy gut microbiota by benignly altering their composition. These findings suggested that green spaces should be designed to support diverse gut microbiota and ultimately optimize health benefits.