Uveitis as a Confounding Factor in Retinal Nerve Fiber Layer Analysis Using Optical Coherence Tomography. (17th February 2022)

• Record Type: Journal Article
• Authors: Yilmaz, Hayati; Koylu, Mehmet Talay; Çakır, Bağım Ayçin; Küçükevcilioğlu, Murat; Durukan, Ali Hakan; Bayer, Atilla; Mutlu, Fatih Mehmet
• Is Part Of: Ocular immunology and inflammation. Volume 30:Number 2(2022)
• Page Start: 386
• Page End: 391
• Publication Date: 2022-02-17
• Subjects: Uveitis -- glaucoma -- retinal nerve fiber layer -- optical coherence tomography; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2020.1811353
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose: To investigate the retinal nerve fiber layer thickness (RNFLT) in uveitic eyes and search for the associations with uveitis activity, etiology and location. Methods: The files of 76 patients with uveitis and 76 controls were scanned. Associations of RNFLT were analyzed using generalized linear models. Results: The RNFLT was significantly higher in patients with uveitis ( p < .001). Active uveitis patients had a thicker RNFL than the controls and the patients with quiescent uveitis ( p < .001). Anterior uveitis was associated with thinner RNFL in global and inferotemporal quadrant ( p = .011 and 0.013, respectively). Thickening of RNFL was associated with posterior uveitis and Behçet's disease in all quadrants ( p < .001) and idiopathic uveitis in the superonasal and nasal quadrants ( p = .001). Conclusion: Active uveitis, as well as posterior uveitis and Behcet's disease-associated uveitis, is a major confounding factor in RNFL analysis and therefore detection of glaucoma.