Spiroaquilarenes A–E: unprecedented anti-inflammatory sesquiterpene polymers from agarwood of Aquilaria sinensis. Issue 8 (25th February 2022)

• Record Type: Journal Article
• Authors: Huang, Xiao-Ling; Yan, Yong-Ming; Wang, Dai-Wei; Cheng, Yong-Xian
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 8(2022)
• Page Start: 2070
• Page End: 2078
• Publication Date: 2022-02-25
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo00066k
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Spiroaquilarenes A–E (1–5 ), a class of sesquiterpene polymers featuring unusual furaneol rings connecting sesquiterpene units, were isolated from agarwood of Aquilaria sinensis and structurally characterized. Abstract : Spiroaquilarenes A–E (1–5 ), a class of sesquiterpene polymers featuring unusual furaneol rings connecting sesquiterpene units, were isolated from agarwood of Aquilaria sinensis . Their structures were identified by spectroscopic analyses and computational methods. Compounds 2 and 3 were found to dose-dependently inhibit the production of TNF-α, IL-6, and nitrite oxide and the activation of NF-κB in LPS-induced RAW264.7 cells.