Clinical recrudescence of chronic untreated P. malariae infection after BNT162b2 CoVID-19 vaccine. (2022)

• Record Type: Journal Article
• Authors: Ciusa, G.; Guida Marascia, F.; Virruso, R.; Angheben, A.; Guaraldi, G.; Cascio, A.
• Is Part Of: IDCases. Volume 27(2022)
• Publication Date: 2022
• Subjects: Plasmodium malariae -- Malaria -- Chronic malaria -- CoVID-19 vaccine -- BNT162b2; Communicable diseases -- Periodicals; Communicable Diseases -- Case Reports; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; 616.9
• DOI: 10.1016/j.idcr.2022.e01456
• Languages: English
• ISSNs: 2214-2509

Abstract

Abstract: We described a case of clinical reactivation of chronic P. malariae infection following CoVID-19 vaccination with BNT162b2 (Pifzer-Biontech CoVID-19 vaccine) in a 48-year old Italian man.The patient came to our attention for fever of unknown origin show a quartan pattern (every third day) associated to splenomegaly, the onset of the fever occurred one month after CoVID-19 vaccination with BNT162b2. P. malariae was diagnosed using Carestart™ malaria rapid test and Polymerase-Chain Reaction. Post-vaccine transient reduction of immune reactivity is described in literature, although the mechanism is unknown.