Near infrared spectroscopy to evaluate the effect of a hybrid exercise programme on peripheral muscle metabolism in patients with intermittent claudication: an exploratory PROSECO-IC sub study. Issue 9 (3rd May 2022)

• Record Type: Journal Article
• Authors: Cornelis, Nils; Chatzinikolaou, Panagiotis N; Buys, Roselien; De Wilde, Camille; Fourneau, Inge; Claes, Jomme; Goetschalckx, Kaatje; Cornelissen, Véronique
• Is Part Of: Journal of sports sciences. Volume 40:Issue 9(2022)
• Page Start: 1031
• Page End: 1041
• Publication Date: 2022-05-03
• Subjects: Near-infrared spectroscopy -- lower-extremity artery disease -- intermittent claudication -- muscle oxygenation -- exercise training; Sports -- Periodicals; Sports -- Physiological aspects -- Periodicals; Sports -- Psychological aspects -- Periodicals; 612.044
• DOI: 10.1080/02640414.2022.2045062
• Languages: English
• ISSNs: 0264-0414

Abstract

ABSTRACT: Intermittent claudication (IC) is characterized by decreased blood flow and oxygen delivery to the lower-limb muscles, resulting in pain and impaired functional capacity. This study evaluated the effects of a 12-week hybrid walking intervention on muscle oxygenation and functional capacity in 38 patients with IC (Rutherford I–III). Functional capacity was evaluated by means of two different treadmill test protocols and a six-minute walk test (6MWT). Muscle oxygenation was assessed during the treadmill tests using near-infrared spectroscopy. After the intervention, maximal walking distance was significantly increased (p < 0.001) during the progressive maximal treadmill test (mean (SD): +155 (SD 177) metres) and 6MWT (+18 (SD 29) metres) metres, with concomitant improvements in muscle oxygenation measures. Deoxygenation was slower during the progressive maximal test (p < 0.001) and reoxygenation was faster during recovery (p = 0.045). During the more submaximal test, oxygenated haemoglobin was better preserved (p = 0.040). Slower deoxygenation was more pronounced in the high responders of the progressive maximal treadmill test (p = 0.002). The findings suggest that preserved oxygen availability and slower deoxygenation during exercise could partly explain the improvements in functional capacity.