Determination of antimalarial drugs in pharmaceutical formulations and human blood by liquid chromatography: a review. Issue 39 (6th October 2021)

• Record Type: Journal Article
• Authors: Penna, Eduarda Alves; de Souza, Jéssica Cordeiro Queiroz; de Oliveira, Marcone Augusto Leal; Chellini, Paula Rocha
• Is Part Of: Analytical methods. Volume 13:Issue 39(2021)
• Page Start: 4557
• Page End: 4584
• Publication Date: 2021-10-06
• Subjects: Chemistry, Analytic -- Periodicals; Analytical biochemistry -- Periodicals; Chemical laboratories -- Standards -- Periodicals; 543.1905
• DOI: 10.1039/d1ay01173a
• Languages: English
• ISSNs: 1759-9660

Abstract

Abstract : The evolution of different analytical methods that have been applied to the determination of antimalarial drugs in pharmaceutical formulations and human blood by liquid chromatography. Abstract : Malaria is a life-threatening disease being treated by oral medication. This is the best treatment to reduce morbidity and mortality, prevent disease progression to the most severe form, lower the transmission of the disease and hinder the appearance of strains resistant to antimalarials. According to the World Health Organization, the most common antimalarial drugs are chloroquine, primaquine, mefloquine, lumefantrine, artemether, and artesunate in single dosage forms or fixed-dose combination. Within this context, the present review aims to show the evolution of different analytical methods that have been applied to the determination of these antimalarial drugs in pharmaceutical formulations and human blood by liquid chromatography in the last 10 years, along with statistical analyses of the methods.