Mapping vitamin B6 metabolism by hydrazoCEST magnetic resonance imaging. Issue 83 (31st August 2021)

• Record Type: Journal Article
• Authors: Brun, Emilie Marie Sophie Patit-Tha; Calvert, Nicholas David; Suchý, Mojmír; Kirby, Alexia; Melkus, Gerd; Garipov, Ruslan; Addison, Christina L.; Shuhendler, Adam J.
• Is Part Of: Chemical communications. Volume 57:Issue 83(2021)
• Page Start: 10867
• Page End: 10870
• Publication Date: 2021-08-31
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc03704h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : 2-Hydrazinonicotinic acid can selectively map the critical coenzyme pyridoxal 5′-phosphate by CEST-MRI in vitro and in vivo . Abstract : A new CEST-MRI contrast agent, 2-HYNIC, capable of sensing aromatic aldehydes is reported. Pyridoxal 5′-phosphate, a key Vitamin B6 metabolite necessary for >140 biotransformations was mapped by CEST-MRI in vitro and in vivo in lung cancer. 2-HYNIC provided access to this key biomarker associated with a variety of human diseases.