Electrochemical-induced hydroxylation of aryl halides in the presence of Et3N in water. Issue 29 (8th July 2021)

• Record Type: Journal Article
• Authors: Yang, Li; Zhuang, Qinglong; Wu, Mei; Long, Hua; Lin, Chen; Lin, Mei; Ke, Fang
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 29(2021)
• Page Start: 6417
• Page End: 6421
• Publication Date: 2021-07-08
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob00931a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A thorough study of mild and environmentally friendly electrochemical-induced hydroxylation of aryl halides without a catalyst is presented. Abstract : A thorough study of mild and environmentally friendly electrochemical-induced hydroxylation of aryl halides without a catalyst is presented. The best protocol consists of hydroxylation of different aryl iodides and aryl bromides by water solution in the presence of Et3 N under air, affording the target phenols in good isolated yields. Moreover, aryl chlorides were successfully employed as substrates. This methodology also provides a direct pathway for the formation of deoxyphomalone, which displayed a significant anti-proliferation effect.