Electro-oxidative cyclization: access to quinazolinones via K2S2O8 without transition metal catalyst and base. Issue 50 (24th September 2021)

• Record Type: Journal Article
• Authors: Hu, Yongzhi; Hou, Huiqing; Yu, Ling; Zhou, Sunying; Wu, Xianghua; Sun, Weiming; Ke, Fang
• Is Part Of: RSC advances. Volume 11:Issue 50(2021)
• Page Start: 31650
• Page End: 31655
• Publication Date: 2021-09-24
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1ra05092c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A K2 S2 O8 -promoted oxidative tandem cyclization of primary alcohols with 2-aminobenzamides to synthesize quinazolinones was successfully achieved under undivided electrolytic conditions without a transition metal and base. Abstract : A K2 S2 O8 -promoted oxidative tandem cyclization of primary alcohols with 2-aminobenzamides to synthesize quinazolinones was successfully achieved under undivided electrolytic conditions without a transition metal and base. The key feature of this protocol is the utilization of K2 S2 O8 as an inexpensive and easy-to-handle radical surrogate that can effectively promote the reaction via a simple procedure, leading to the formation of nitrogen heterocycles via direct oxidative cyclization at room temperature in a one-pot procedure under constant current. Owing to the use of continuous-flow electrochemical setups, this green, mild and practical electrosynthesis features high efficiency and excellent functional group tolerance and is easy to scale up.