Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation. Issue 30 (16th March 2022)

• Record Type: Journal Article
• Authors: Wang, Bo; Bruhn, Jessica F.; Weldeab, Asmerom; Wilson, Timothy S.; McGilvray, Philip T.; Mashore, Michael; Song, Qiong; Scapin, Giovanna; Lin, Yiqing
• Is Part Of: Chemical communications. Volume 58:Issue 30(2022)
• Page Start: 4711
• Page End: 4714
• Publication Date: 2022-03-16
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc00221c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : One can confidently assign the absolute configuration of a chiral molecule using crystalline powders, via microcrystal electron diffraction (MicroED) analysis. Abstract : Microcrystal electron diffraction (MicroED) has established its complementary role alongside X-ray diffraction in crystal structure elucidation. Unfortunately, kinematical refinement of MicroED data lacks the differentiation power to assign the absolute structure solely based on the measured intensities. Here we report a method for absolute configuration determination via MicroED by employing salt formation with chiral counterions.