A stereoselective hydride transfer reaction with contributions from attractive dispersion force control. Issue 32 (24th March 2022)

• Record Type: Journal Article
• Authors: Braddock, D. Christopher; Limpaitoon, Natnicha; Oliwa, Krzysztof; O'Reilly, Daniel; Rzepa, Henry S.; White, Andrew J. P.
• Is Part Of: Chemical communications. Volume 58:Issue 32(2022)
• Page Start: 4981
• Page End: 4984
• Publication Date: 2022-03-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc01136k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The experimentally determined stereochemical outcome of an unprecedented hydride transfer from a lithium alkoxide to an aldehyde is reported, as deconvoluted by the combined use of a single enantiomer alkoxide in conjunction with a deuterium label. Abstract : The experimentally determined stereochemical outcome of an unprecedented hydride transfer from a lithium alkoxide to an aldehyde is reported, as deconvoluted by the combined use of a single enantiomer alkoxide in conjunction with a deuterium label. The stereoselective outcome is consistent with a computationally predicted transition state model stabilised by contributions from attractive dispersion forces.