Metal-free regioselective cascade sulfonylation–cyclization of 3-aza-1, 5-enynes with sulfur dioxide and aryldiazonium tetrafluoroborates to construct 1, 2-dihydropyridines. Issue 8 (17th March 2022)

• Record Type: Journal Article
• Authors: Ding, Ran; Deng, Yu-Hang; Luo, Shan; Tang, Xue-Feng; Liu, Lei; Wang, Pei-Long
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 8(2022)
• Page Start: 2228
• Page End: 2233
• Publication Date: 2022-03-17
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo00175f
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Radical cascade cyclization of tethered alkynes has emerged as an efficient tool to construct small but complex cyclic compounds. Abstract : Radical cascade cyclization of tethered alkynes has emerged as an efficient tool to construct small but complex cyclic compounds. However, it currently relies on aryl or heteroaryl-tethered alkynes to give benzene-fused molecules. Herein, we describe a regioselective cascade cyclization of vinyl-tethered alkynes, 3-aza-1, 5-enynes. This method features good functional group compatibility and mild conditions and provides an environmentally friendly way to construct 1, 2-dihydropyridines.