The room-temperature, ambient-pressure conversion of CO2 into value-added pharmaceutical products quinazoline-2, 4(1H, 3H)-diones. Issue 37 (16th September 2021)

• Record Type: Journal Article
• Authors: Feng, Xiantao; Wang, Guan; Zheng, Tingting; Zuo, Chunshan; Zhang, Xihong; Fyffe, Phoebe; Chen, Xiaobo
• Is Part Of: Physical chemistry chemical physics. Volume 23:Issue 37(2021)
• Page Start: 21130
• Page End: 21138
• Publication Date: 2021-09-16
• Subjects: Chemistry, Physical and theoretical -- Periodicals; 541.3
• DOI: 10.1039/d1cp03747a
• Languages: English
• ISSNs: 1463-9076

Abstract

Abstract : High conversion yields of quinazoline-2, 4(1 H, 3 H )-diones (91.5–99.3%) can be achieved at room temperature and under ambient pressure using a [HDBU + ][3-Cl-PhO − ] ionic liquid catalyst. Abstract : As global warming due to CO2 emissions has become a widely recognized concern, CO2 capture, sequestration, neutralization, and conversion have become possible solutions to address this concern. Among these approaches, the conversion of CO2 into fuels or value-added products has attracted considerable attention. In this work, we report the high-efficiency conversion of CO2 to important industrial raw materials for pharmaceutical compounds, quinazoline-2, 4(1 H, 3 H )-diones, via reactions with 2-aminobenzonitriles at room temperature and under ambient pressure, with high conversion yields (91.5–99.3%). 1, 8-Diazabicyclo-[5.4.0]-undec-7-ene (DBU), 1, 1, 3, 3-tetramethylguanidine (TMG), and cholinium (Ch) ammonium-based ionic liquids (ILs) are employed as catalysts during the process. Cations with a p K a value near 11.9 and anions with a p K a value range of 10 to 15 are necessary for the reaction. The experimental results indicate that the ionic liquid pair [HDBU + ][3-Cl-PhO − ] has high efficiency under very mild conditions, obtaining high product yields of 91.5% at 25 °C and 1 atm and 99.3% at 30 °C and 1 atm. More importantly, the catalysts retain high efficiency and activity after 5 consecutive cycles. To gain insightful understanding of the reaction, density functional theory (DFT) calculations were conducted to study the reaction mechanism. The computational results indicate that the catalytic process contains three stages: cyano activation, intramolecular rearrangement, and intramolecular cyclization. Of these, the rate-determining step is cyano activation, which shows an energy barrier of 24.5 kcal mol −1 . Tuning the types of ions in ILs can effectively reduce this energy barrier and allow high efficiencies.