A novel site-induced biomolecule anchoring strategy based on solid superacid ZrO2/SO42- for fabricating label-free IgG electrochemical immunosensors. (1st June 2021)

• Record Type: Journal Article
• Authors: Chen, Xiaoyan; Song, Lin; Zhu, Guanyang; Ma, Jing; Xu, Ajing; Zhao, Wenya; Gu, Yingying; An, Yarui; Miao, Yuqing
• Is Part Of: New journal of chemistry. Volume 45:Number 24(2021)
• Page Start: 10850
• Page End: 10856
• Publication Date: 2021-06-01
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d1nj01279g
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : In this work, a unique zirconium dioxide solid superacid (ZrO2 /SO4 2− ) was utilized for the fabrication of an IgG electrochemical immunosensor. Abstract : In this work, a unique zirconium dioxide solid superacid (ZrO2 /SO4 2− ) was utilized for the fabrication of an IgG electrochemical immunosensor. The treated ZrO2 formed a SO bond on the surface, which has the electron-attracting induction effect and can further enhance the quantity and stability of immobilized biomolecules. In addition, using a platinum nanoparticle–chitosan–reduced graphene oxide (PtNP–CHIT–rGO) nanocomposite as a substrate modification material not only improves the conductivity of the electrode, but also increases the effective surface area of the immunosensing platform. The proposed label-free immunosensor has a lower detection limit of 11.0 pg mL −1 and a wide linear range of 0.01–10.0 ng mL −1 and 10.0–4000.0 ng mL −1 . Importantly, the immunosensor exhibits good selectivity, excellent stability and reproducibility, and is expected to be applied to the detection of other biomolecules.