Electrochemical synthesis of quinazolinone via I2-catalyzed tandem oxidation in aqueous solution. Issue 29 (17th May 2021)

• Record Type: Journal Article
• Authors: Hou, Huiqing; Ma, Xinhua; Lin, Yingying; Lin, Jin; Sun, Weiming; Wang, Lei; Xu, Xiuzhi; Ke, Fang
• Is Part Of: RSC advances. Volume 11:Issue 29(2021)
• Page Start: 17721
• Page End: 17726
• Publication Date: 2021-05-17
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1ra02706a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The development of protocols for synthesizing quinazolinones using biocompatible catalysts in aqueous medium will help to resolve the difficulties of using green and sustainable chemistry for their synthesis. Abstract : The development of protocols for synthesizing quinazolinones using biocompatible catalysts in aqueous medium will help to resolve the difficulties of using green and sustainable chemistry for their synthesis. Herein, using I2 in coordination with electrochemical synthesis induced a C–H oxidation reaction which is reported when using water as the environmentally friendly solvent to access a broad range of quinazolinones at room temperature. The reaction mechanism strongly showed that I2 cooperates electrochemically promoted the oxidation of alcohols, then effectively cyclizing amides to various quinazolinones.