Surface morphology and payload synergistically caused an enhancement of the longitudinal relaxivity of a Mn3O4/PtOx nanocomposite for magnetic resonance tumor imaging. (23rd February 2021)

• Record Type: Journal Article
• Authors: Ji, Sihan; Chen, Yaodong; Zhao, Xianglong; Cai, Yunyu; Zhang, Xiaopeng; Sun, Feilong; Chen, Qi; Deng, Qingmei; Wang, Changhao; Ma, Kun; Hong, Bo; Liang, Changhao
• Is Part Of: Biomaterials science. Volume 9:Number 7(2021)
• Page Start: 2732
• Page End: 2742
• Publication Date: 2021-02-23
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/d0bm01993c
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : A surface porous morphology and PtO x payload synergistically induced an enhancement of the r 1 value to 20.48 mM −1 s −1 in a Mn3 O4 /PtO x nanocomposite for MR imaging. Abstract : The construction of surface structures of manganese oxide nanoparticles (MONs) in order to promote their longitudinal relaxivity r 1 to surpass those of commercially available Gd(iii ) complexes is still a significant challenge. Herein, we successfully obtained Mn3 O4 /PtO x nanocomposites (NCs) with an r 1 of 20.48 mM −1 s −1, four times higher than that of commercially available Gd-DTPA (5.11 mM −1 s −1 ). The r 2 / r 1 ratio of these NCs is 1.46 lower than that of Gd-DTPA (2.38). This is the first time that such excellent T 1 contrast performance has been achieved using MONs via synergistically utilizing the surface morphology and surface payload. These NCs are composed of porous Mn3 O4 "skeleton" nanostructures decorated with tiny PtO x nanoparticles (NPs) that are realized using laser ablation and irradiation in liquid and ion etching steps. Experimental results showed that the enlarged specific area of the porous Mn3 O4 /PtO x NCs and the payload of ultrafine PtO x NPs synergistically facilitated the T 1 contrast capabilities. The former favors sufficient proton–electron interactions and the latter reduces the global molecular tumbling motion. These NCs also exhibit an evident computed tomography (CT) attenuation value of 24.13 HU L g −1, which is much better than that achieved using the commercial product iopromide (15.9 HU L g −1 ). The outstanding magnetic resonance (MR) imaging and CT imaging performances of the Mn3 O4 /PtO x NCs were proved through in vivo experiments. Histological examinations and blood circulation assays confirmed the good biosafety of the NCs. These novel findings showcase a brand-new strategy for fabricating excellent MON T 1 contrast agents (CAs) on the basis of the surface structure and they pave the way for their practical clinical applications in dual-modal imaging.