Vanishing Bile Duct Syndrome Associated With Estrogen. Issue 5 (5th May 2022)

• Record Type: Journal Article
• Authors: Benfield, John; Shah, Raj A.; Grider, Douglas J.; Sahebjam, Farhad
• Is Part Of: ACG Case Reports Journal. Volume 9:Issue 5(2022)
• Page Start: e00776
• Publication Date: 2022-05-05
• DOI: 10.14309/crj.0000000000000776
• Languages: English
• ISSNs: 2326-3253

Abstract

ABSTRACT: Vanishing bile duct syndrome (VBDS) refers to a form of cholestatic liver disease with many etiologies. Vanishing bile duct syndrome is characterized by biliary ductopenia and chronic cholestasis. This is a challenging condition for clinicians because of its rarity and unclear pathophysiology. Presented is an 18-year-old woman who developed cholestatic liver injury and intrahepatic biliary ductopenia after a course of oral contraceptives and intravenous estrogen for uterine bleeding. A year later, this patient did not have significant improvement in liver biomarkers and was referred for transplantation.