Intra-host SARS-CoV-2 single-nucleotide variants emerged during the early stage of COVID-19 pandemic forecast population fixing mutations. Issue 5 (May 2022)

• Record Type: Journal Article
• Authors: Zhang, Yi; Jiang, Ning; Qi, Weiqiang; Li, Tao; Zhang, Yumeng; Zhang, Haocheng; Wu, Jing; Zhu, Zhaoqin; Ai, Jingwen; Qiu, Chao; Zhang, Wenhong
• Is Part Of: Journal of infection. Volume 84:Issue 5(2022)
• Page Start: 722
• Page End: 746
• Publication Date: 2022-05
• Subjects: SARS-CoV-2 -- Intra-host single-nucleotide variants -- COVID-19 -- Fixed mutation; Infection -- Periodicals; Bacterial Infections -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.905
• DOI: 10.1016/j.jinf.2022.01.016
• Languages: English
• ISSNs: 0163-4453

Abstract

Highlights: A large proportion of iSNVs could be found in the several dominant VOCs in early-stage samples. iSNVs located spike protein may help in immune escape forecasting. The dominant C-U/G-A in iSNVs indicate APOBEC driven SARS-CoV-2 to adaptation.