The molecular mechanisms that drive intracellular neutralization by the antibody-receptor and RING E3 ligase TRIM21. (June 2022)
- Record Type:
- Journal Article
- Title:
- The molecular mechanisms that drive intracellular neutralization by the antibody-receptor and RING E3 ligase TRIM21. (June 2022)
- Main Title:
- The molecular mechanisms that drive intracellular neutralization by the antibody-receptor and RING E3 ligase TRIM21
- Authors:
- Kiss, Leo
James, Leo C. - Abstract:
- Abstract: The cytosolic antibody receptor and RING E3 ligase TRIM21 targets intracellular, antibody-coated immune complexes for degradation and activates the immune system. Here we review how TRIM21 degrades diverse targets and how this activity can be exploited in molecular biology and for the development of new therapeutics. In addition, we compare what is known about TRIM21′s mechanism to other TRIM proteins and RING E3 ligases.
- Is Part Of:
- Seminars in cell & developmental biology. Volume 126(2022)
- Journal:
- Seminars in cell & developmental biology
- Issue:
- Volume 126(2022)
- Issue Display:
- Volume 126, Issue 2022 (2022)
- Year:
- 2022
- Volume:
- 126
- Issue:
- 2022
- Issue Sort Value:
- 2022-0126-2022-0000
- Page Start:
- 99
- Page End:
- 107
- Publication Date:
- 2022-06
- Subjects:
- TRIM21 -- Antibody -- Trim-Away -- Intracellular neutralization -- Virus -- E3 ubiquitin ligase
Cytology -- Periodicals
Developmental biology -- Periodicals
571.6 - Journal URLs:
- http://www.sciencedirect.com/science/journal/10849521 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.semcdb.2021.11.005 ↗
- Languages:
- English
- ISSNs:
- 1084-9521
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8239.448346
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 21345.xml