Effect of point-of-care influenza tests on antibiotic prescriptions by emergency physicians in a French hospital. (April 2022)

• Record Type: Journal Article
• Authors: Berwa, A.; Gallouche, M.; Larrat, S.; Fauconnier, J.; Viglino, D.; Bosson, J.L.; Landelle, C.
• Is Part Of: Journal of hospital infection. Volume 122(2022)
• Page Start: 133
• Page End: 139
• Publication Date: 2022-04
• Subjects: Influenza -- Point-of-care tests -- Emergency department -- Antibiotic prescriptions; Cross infection -- Periodicals; Cross infection -- Prevention -- Periodicals; Nosocomial infections -- Periodicals; Nosocomial infections -- Prevention -- Periodicals; Cross Infection -- Periodicals; Cross Infection -- prevention & control -- Periodicals; Infection Control -- Periodicals; Electronic journals; 614.44
• DOI: 10.1016/j.jhin.2022.01.014
• Languages: English
• ISSNs: 0195-6701

Abstract

Summary: Background: Influenza is a public health issue worldwide. Although antibiotics should not be used to treat viral infections, they are often prescribed to patients with influenza-like illness (ILI). Such misuse promotes antibiotic resistance. The role of rapid point-of-care tests (POCTs) in preventing antibiotic misuse in adults with ILI symptoms remains relatively unexplored. Aim: To evaluate whether POCT implemented in 2018–2019 to detect influenza viruses led to a decrease in antibiotic prescriptions compared with laboratory-based influenza tests. Methods: Adult patients with ILI in one emergency department (ED) were retrospectively enrolled over three epidemic seasons (from 2016–2017 to 2018–2019). The primary outcome was the rate of antibiotic prescriptions, which was compared between the three seasons in bivariate and multivariate analyses. Prescriptions for ancillary laboratory tests, chest X-rays and oseltamivir were also compared, along with hospitalizations and length of stay (LOS) at the ED. Findings: Overall, 1849 patients were included. Median age was over 70 years throughout all three seasons. The number of antibiotic prescriptions was significantly different between the three periods in bivariate analysis (48.3% in 2016/2017, 44% in 2017/2018 and 31.1% in 2018/2019; P <0, 0001) and in multivariate analysis (adjusted odds ratio (aOR) = 0.48, 95% confidence interval (CI) = 0.30–0.76 for 2018/2019 and aOR = 0.99, 95%CI = 0.67–1.46 for 2017/2018, compared with 2016/2017). There were significantly fewer prescriptions of ancillary laboratory tests, X-rays, hospitalizations and more oseltamivir prescriptions in 2018/2019, compared with the previous seasons. LOS was significantly lower in 2018/2019 only for influenza-positive patients. Conclusions: ED influenza POCT decreased antibiotic use and led to less ancillary testing, X-rays and hospitalizations among patients with ILI. However, medico-economic studies are necessary before formulating definite recommendations.