Evaluation of the substitution of poliomyelitis virus for testing virucidal activities of instrument and surface disinfection. (April 2022)

• Record Type: Journal Article
• Authors: Steinmann, J.; Eggers, M.; Rapp, I.; Todt, D.; Steinmann, E.; Brill, F.H.H.; Schwebke, I.
• Is Part Of: Journal of hospital infection. Volume 122(2022)
• Page Start: 60
• Page End: 63
• Publication Date: 2022-04
• Subjects: Virucidal activity -- Poliovirus type 1 -- Murine parvovirus -- Suspension test -- Biocidal substances; Cross infection -- Periodicals; Cross infection -- Prevention -- Periodicals; Nosocomial infections -- Periodicals; Nosocomial infections -- Prevention -- Periodicals; Cross Infection -- Periodicals; Cross Infection -- prevention & control -- Periodicals; Infection Control -- Periodicals; Electronic journals; 614.44
• DOI: 10.1016/j.jhin.2021.12.022
• Languages: English
• ISSNs: 0195-6701

Abstract

Summary: The Global Polio Eradication initiative has the goal to eradicate poliomyelitis worldwide. This means that poliomyelitisvirus type 1 strain LSc 2ab (PV-1) can no longer be used for the evaluation of virucidal activity of chemical disinfectants. This study evaluated murine parvovirus ATCC VR 1346 (minute virus of mice) as suitable surrogate for PV-1 when testing virucidal activity of biocides in instrument and surface disinfectants. Suspension testing in different laboratories with two commercially available active biocidal substances based on glutaraldehyde (0.01–0.25%) and peracetic acid (0.005–0.1%) with an exposure time of 30 min was performed. Both pathogens showed comparable susceptibility and dose-dependent reduction of virus titres following German and European Guidelines.