Frontal language areas do not emerge in the absence of temporal language areas: A case study of an individual born without a left temporal lobe. (3rd May 2022)

• Record Type: Journal Article
• Authors: Tuckute, Greta; Paunov, Alexander; Kean, Hope; Small, Hannah; Mineroff, Zachary; Blank, Idan; Fedorenko, Evelina
• Is Part Of: Neuropsychologia. Number 169(2022)
• Publication Date: 2022-05-03
• Subjects: Language development -- Case study -- Neuroimaging -- Plasticity; Neuropsychology -- Periodicals; Neurology -- Periodicals; Psychophysiology -- Periodicals; Neuropsychologie -- Périodiques; Neuropsychology; Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.neuropsychologia.2022.108184
• Languages: English
• ISSNs: 0028-3932

Abstract

Abstract: Language processing relies on a left-lateralized fronto-temporal brain network. How this network emerges ontogenetically remains debated. We asked whether frontal language areas emerge in the absence of temporal language areas through a 'deep-data' investigation of an individual (EG) born without her left temporal lobe. Using fMRI methods that have been validated to elicit reliable individual-level responses, we find that—as expected for early left-hemisphere damage—EG has a fully functional language network in her right hemisphere (comparable to the LH network in n = 145 controls) and intact linguistic abilities. However, we detect no response to language in EG's left frontal lobe (replicated across two sessions, 3 years apart). Another network—the multiple demand network—is robustly present in frontal lobes bilaterally, suggesting that EG's left frontal cortex can support non-linguistic cognition. The existence of temporal language areas therefore appears to be a prerequisite for the emergence of the frontal language areas. Highlights: No response to language was detected in the left frontal lobe of an individual (EG) born without her left temporal lobe. Responses to language in EG's dominant (right) hemisphere were comparable to the dominant hemisphere in controls. Responses to a working memory task were robustly detected in the left frontal lobe of EG. The findings suggest that temporal language areas are necessary for the emergence of frontal language areas.