Prospective observational study of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck in Gunma University. Issue 3 (May 2022)

• Record Type: Journal Article
• Authors: Musha, Atsushi; Kubo, Nobuteru; Okano, Naoko; Kaminuma, Takuya; Kawamura, Hidemasa; Sato, Hiro; Takayasu, Yukihiro; Shino, Masato; Nikkuni, Osamu; Ida, Shota; Shirai, Katsuyuki; Saitoh, Jun-ichi; Ogawa, Masaru; Yokoo, Satoshi; Chikamatsu, Kazuaki; Ohno, Tatsuya
• Is Part Of: Journal of oral and maxillofacial surgery, medicine, and pathology. Volume 34:Issue 3(2022)
• Page Start: 280
• Page End: 286
• Publication Date: 2022-05
• Subjects: C-ion RT carbon-ion radiotherapy -- CTCAE Common Terminology Criteria for Adverse Events -- MR magnetic resonance -- QOL quality of life -- RBE relative biological effectiveness; Carbon-ion radiotherapy -- Non-squamous cell carcinoma; Mouth -- Surgery -- Periodicals; Face -- Surgery -- Periodicals; Maxilla -- Surgery -- Periodicals; Oral medicine -- Periodicals; Mouth -- Diseases -- Pathogenesis -- Periodicals; Surgery, Oral -- Periodicals; Oral Medicine -- Periodicals; Pathology, Oral -- Periodicals; Face -- Surgery; Maxilla -- Surgery; Mouth -- Diseases -- Pathogenesis; Mouth -- Surgery; Oral medicine; Electronic journals -- Sciences; Electronic journals -- Medicine; Periodicals; 617.522059
• DOI: 10.1016/j.ajoms.2021.10.012
• Languages: English
• ISSNs: 2212-5566

Abstract

Abstract: Objective: Data on the long-term outcomes of carbon-ion radiotherapy for non-squamous cell carcinomas are rare. Gunma University has been utilizing carbon-ion radiotherapy as a treatment for head and neck cancer since 2010. This study aimed to evaluate the long-term efficacy and safety of carbon-ion radiotherapy for the head and neck. Methods: We prospectively evaluated 35 patients with non-squamous cell carcinoma who underwent carbon-ion radiotherapy at Gunma University Heavy Ion Medical Center between 2010 and 2014. The 5-year local control, overall survival, and progression-free survival rates were evaluated. Results: The median age was 59 years (range, 31–77 years), and the median follow-up time was 65 months (range, 6.1–98.8 months). Overall, 32 and 3 patients received 64.0 Gy (relative biological effectiveness) and 57.6 Gy (relative biological effectiveness) in 16 fractions, respectively. Adenoid cystic carcinoma was the most dominant histopathological type (n = 21 patients, 60 %). The 5-year local control, progression-free survival, and overall survival rates were 74.5 %, 53.2 %, and 81.3 %, respectively. Nine patients had local recurrence, and six patients died. Adverse events included acute grade 3 radiation mucositis (Common Terminology Criteria for Adverse Events version 4.0) in 8 patients; this was improved immediately with conservative therapy. Late grade 4 adverse events were observed, including two cases of visual loss and one case of brain necrosis. No grade 5 adverse events were observed. Conclusion: Carbon-ion radiotherapy achieves excellent local control and overall survival rates in non-squamous cell carcinoma patients with expected adverse events.