Persistent Immune Activation in Human Immunodeficiency Virus–Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception. (29th March 2021)

• Record Type: Journal Article
• Authors: Lohman-Payne, Barbara; Koster, Jacob; Gabriel, Benjamin; Chilengi, Roma; Forman, Leah S; Heeren, Tim; Duffy, Cassandra R; Herlihy, Julie; Crimaldi, Steven; Gill, Chris; Chavuma, Roy; Mwananyanda, Lawrence; Thea, Donald M
• Is Part Of: Journal of infectious diseases. Volume 225:Number 7(2022)
• Page Start: 1162
• Page End: 1167
• Publication Date: 2021-03-29
• Subjects: Zambia -- Mother-Child health -- HIV-positive -- HIV-negative -- pregnancy -- CD38 -- HLA-DR; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiab095
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: This study evaluated the impact of human immunodeficiency virus (HIV) and combination antiretroviral therapy (cART) on immune activation during pregnancy in a Zambian cohort of HIV-exposed but uninfected children followed up from birth. Activated CD8 + T cells (CD38 + and HLA-DR + ) were compared among HIV-uninfected (n = 95), cART experienced HIV-infected (n = 111), and cART-naive HIV-infected (n = 21) pregnant women. Immune activation was highest among HIV-infected/cART-naive women but decreased during pregnancy. Immune activation HIV-infected women who started cART during pregnancy was reduced but not to levels similar to those in HIV-uninfected women. The effects of elevated maternal immune activation in pregnancy on subsequent infant health and immunity remain to be determined. Abstract : Human immunodeficiency virus (HIV)–infected women who started combination antiretroviral therapy (cART) during pregnancy experienced reduced T-cell immune activation but not to levels similar to those in pregnant cART-experienced HIV-infected or HIV-uninfected women. The effect of maternal immune activation during early life on infant immunity remains undefined.