Clinical and Radiologic Manifestations of Cat-Scratch Osteomyelitis in Children. (4th October 2017)

• Record Type: Journal Article
• Authors: Erdem, Guliz; Shorbatli, Loujain; Watson, Joshua; Hunt, W Garrett; Young, Cody; Nahata, Milap; Souverbielle, Cristina Tomatis; Koranyi, Katalin
• Is Part Of: Open forum infectious diseases. Volume 4(2017)Supplement 1
• Page Start: S677
• Page End: S677
• Publication Date: 2017-10-04
• Subjects: Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofx163.1809
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Background: Osteomyelitis (OM) is a rare sequela of cat scratch disease (CSD), often with atypical bone involvement. Clinical presentation of CSD OM is not well described. We sought to determine the clinical and radiologic manifestations of CSD OM patients admitted to Nationwide Children's Hospital. Methods: EMR of inpatients was reviewed between January 2010 and March 2017. Clinical, radiological, and histopathological findings were c ollected. Results: Nine patients with positive cat scratch serology and/or tissue PCR were identified. Mean age was 6 years and 8 months (range 3–12 years). Patients had a prolonged course of illness before the diagnosis was made (mean 9.7 days). All patients had fever and affected bone area pain. Patients had normal WBC (mean 11, 800/mm3) and modest ESR (mean 53.2 mm/hours) and CRP (mean 5.2 mg/dl) elevations on admission. Six patients had osteomyelitis at ≥ 2 sites (multifocal) with no contiguous lymphadenopathy (LAD). The vertebrae and pelvic girdle were the most common sites. Two patients had contiguous paraspinal abscesses, and 1 patient had a concomitant lymph node (LN) abscess. No osteolytic lesions were identified. Serology in all (9 of 9 IgG, 7 of 9 IgM) and PCR of bone in 2 of 2 patients were positive. All patients received antimicrobial therapy with median duration of 28 days (IQR 15–50). Conclusion: CSD OM has an indolent course of illness with moderate elevation of inflammatory markers. Unlike previous reports of CSD and other bacterial OM, multifocal osteomyelitis without contiguous LN involvement was common. Despite significant variations in treatment duration and antimicrobial therapy choices, all patients had clinical resolution of their CSD-associated disease. Disclosures: All authors: No reported disclosures.