An efficient and scalable synthesis of Isodesmosine. (3rd February 2022)

• Record Type: Journal Article
• Authors: Gupta, Aikan; Sharma, Yogesh; Pawar, Ganesh P.; Ashish, ; Nihalani, Deepak; Chaudhari, Vinod D.
• Is Part Of: Journal of heterocyclic chemistry. Volume 59:Number 5(2022)
• Page Start: 958
• Page End: 963
• Publication Date: 2022-02-03
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.4441
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract: Isodesmosine is 1, 2, 3, 5‐tetrasubstituted pyridinium‐based amino acid substituted with four lysine derivatives found in elastin which is the main component of elastic fiber. Elastin plays a vital role in providing stretchy properties to tissues and body organs. Isodesmsoine is a proven to be useful biomarker for elastin degradation during the progressing stage of chronic obstructive pulmonary disease (COPD) and related diseases. The present work reported an efficient and gram‐scale approach for the synthesis of Isodesmosine, starting from readily available Boc‐Asp‐O t Bu using mild reaction conditions. Abstract :