Renal metastasis of ovarian granulosa cell tumor. Issue 3 (21st March 2022)

• Record Type: Journal Article
• Authors: Togashi, Kyo; Yoneyama, Tohru; Sutoh Yoneyama, Mihoko; Yamamoto, Hayato; Hatakeyama, Shingo; Yoneyama, Takahiro; Hashimoto, Yasuhiro; Futagami, Masayuki; Ohyama, Chikara
• Is Part Of: IJU case reports. Volume 5:Issue 3(2022)
• Page Start: 186
• Page End: 190
• Publication Date: 2022-03-21
• Subjects: adult granulosa cell tumor -- c134w mutation -- FOXL2 -- renal metastasis; Urology -- Periodicals; Genitourinary organs -- Periodicals; Electronic journals; Periodicals; 616.6
• DOI: 10.1002/iju5.12433
• Languages: English
• ISSNs: 2577-171X

Abstract

Abstract : Introduction: We would like to present a rare case of metastatic renal tumor. Case presentation: A 60‐year‐old woman presented to our department with a left renal tumor. She underwent a total hysterectomy and right adnexal resection for a stage IA ovarian granulosa cell tumor approximately 15 years ago, followed by left adnexal resection and postoperative chemotherapy with gemcitabine and paclitaxel 6 years ago. She received six courses of gemcitabine and carboplatin to treat a stage IC clear cell adenocarcinoma of the ovary. The patient was diagnosed with the left renal tumor and underwent a laparoscopic left nephrectomy. Immunostaining was positive for α‐inhibin and SF‐1 and showed FOXL2 402C→G (C134W) mutation. Finally, the patient was diagnosed with renal metastasis of a granulosa cell tumor. Conclusion: To our knowledge, this is a very rare case of renal metastasis of a granulosa cell tumor with the FOXL2 mutation in an adult.