Palladium‐Catalyzed Aminocarbonylation of Heteroaryl Iodides. Issue 16 (25th April 2022)

• Record Type: Journal Article
• Authors: Gajanan, ; Rathod, K.; Jain, Rahul
• Is Part Of: ChemistrySelect. Volume 7:Issue 16(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-04-25
• Subjects: Aminocarbonylation -- Chloroform -- Diaminocarbonylation -- Palladium-catalyzed -- Quinolines; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202200773
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Palladium‐catalyzed aminocarbonylation of heteroaryl iodides is reported in the presence of chloroform as the carbon monoxide surrogate. The substrate scope of the reaction was demonstrated by the synthesis of quinoline‐3‐carboxamides and other heteroaryl amides in yields up to 90 % under non‐inert conditions and microwave irradiation at 80 °C in 30 min. This carbonylation method provides efficient access to previously inaccessible biologically important heteroaryl carboxamides. Abstract : Easy access to a series biologically important heteroaryl carboxamide within short reaction time under mild reaction condition by palladium‐catalyzed aminocarbonylation using chloroform as CO surrogate under the assistance of microwave irradiation is reported. The substrate scope of the reaction was demonstrated by the synthesis of quinoline‐3‐carboxamides and other heteroaryl amides under microwave irradiation at 80 °C in 30 min. The method was successfully applied to one‐pot diaminocarbonylation reaction in high yield.