Efficacy of cytapheresis for induction therapy and extra‐intestinal skin manifestations of ulcerative colitis. Issue 3 (10th March 2022)

• Record Type: Journal Article
• Authors: Shibuya, Tomoyoshi; Nomura, Osamu; Nomura, Kei; Haraikawa, Mayuko; Haga, Keiichi; Ishikawa, Dai; Osada, Taro; Yamaji, Ken; Ikeda, Shigaku; Nagahara, Akihito
• Is Part Of: Therapeutic apheresis and dialysis. Volume 26:Issue 3(2022)
• Page Start: 522
• Page End: 528
• Publication Date: 2022-03-10
• Subjects: cytapheresis -- erythema nodosum -- extra‐intestinal manifestation -- pyoderma gangrenosum -- ulcerative colitis; Hemapheresis -- Periodicals; Dialysis -- Periodicals; Blood Component Removal -- Periodicals; Renal Dialysis -- Periodicals; Hémaphérèse -- Périodiques; Dialyse -- Périodiques; Sang -- Collecte et conservation -- Périodiques; 616
• DOI: 10.1111/1744-9987.13823
• Languages: English
• ISSNs: 1744-9979

Abstract

Abstract: Introduction: In recent years, the prevalence of inflammatory bowel diseases has been increasing in Japan due to the westernization of lifestyles. Many patients have been reported to have extra‐intestinal manifestations (EIMs) at least once. Skin lesions occur with a high degree of frequency among EIMs, with erythema nodosum (EN) and pyoderma gangrenosum (PG) the main complications. Cytapheresis is again attracting attention as a treatment with few side effects. Methods: We investigated the therapeutic effect of cytapheresis on ulcerative colitis (UC) and cutaneous EIMs. Between 2008 and 2021, 240 patients with active UC had induction therapy by cytapheresis at our hospital. Results: Remission and response rates were 50.0% and 67.5%, respectively. Apheresis was performed on seven patients with PG and five patients with EN with a good response. Serious adverse events were not observed. Conclusion: This retrospective assessment of efficacy showed that EN and PG responded favorably to cytapheresis.