Injectable and self‐healing hydrogels with tissue adhesiveness and antibacterial activity as wound dressings for infected wound healing. Issue 9 (18th January 2022)

• Record Type: Journal Article
• Authors: Zhang, Mengyuan; Lin, Peiling; Song, Xiaofan; Chen, Kun; Yang, Yuxuan; Xu, Yongliang; Zhang, Qiang; Wu, Youshen; Zhang, Yanfeng; Cheng, Yilong
• Is Part Of: Journal of polymer science. Volume 60:Issue 9(2022)
• Page Start: 1511
• Page End: 1520
• Publication Date: 2022-01-18
• Subjects: antibacterial -- hydrogel -- infected wound -- self‐healing -- wound dressing; Polymers -- Periodicals; Polymerization -- Periodicals; Polymerization; Polymers; Periodicals; 547.7
• DOI: 10.1002/pol.20210896
• Languages: English
• ISSNs: 2642-4150

Abstract

Abstract: The design of wound dressings with excellent self‐healing ability, adequate adhesion, good biocompatibility, and potential antibacterial ability is of great significance for the healing of infected wounds arising from human activities. Herein, a series of multi‐functional hydrogel dressings, poly(ionized isocyanoethyl methacrylate‐glutamine)/poly(hexamethylene guanidine) (iGx /PHMGy ) hydrogels, were obtained through homopolymerization of fully ionized isocyanoethyl methacrylate‐glutamine (iIEM‐Gln) in the presence of poly(hexamethylene guanidine) (PHMG), in which strong hydrogen bonds were formed among urea groups in the P (iIEM‐Gln) chain to form a stable hydrogel network. The prepared iGx /PHMGy hydrogels exhibited adequate self‐healing ability and tissue adhesion, which could be firmly adhered to the wound surface and remained intact during application. In addition, the presence of PHMG imparted good antibacterial activity to the hydrogels for the effective promotion of the wound healing in S. aureus infected skin wound on mice. Overall, this multi‐functional hydrogel provides a facile and effective strategy for the design of infected wound dressings, and may show great potential in clinical applications. Abstract :