A Catalyst‐Free Minisci‐Type Reaction: the C–H Alkylation of Quinoxalinones with Sodium Alkylsulfinates and Phenyliodine(III) Dicarboxylates. Issue 41 (22nd October 2019)

• Record Type: Journal Article
• Authors: Wang, Liping; Zhao, Jiquan; Sun, Yuting; Zhang, Hong‐Yu; Zhang, Yuecheng
• Is Part Of: European journal of organic chemistry. Issue 41(2019)
• Page Start: 6935
• Page End: 6944
• Publication Date: 2019-10-22
• Subjects: Minisci‐type reactions -- Quinoxalinones -- Sodium alkylsulfinates -- Phenyliodine(III) dicarboxylates -- Catalyst‐free reaction; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201901266
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : A direct C–H alkylation of quinoxalinones at the C‐3 position with sodium alkylsulfinates and phenyliodine(III) dicarboxylates has been developed under catalyst‐free conditions. A series of 3‐alkylquinoxalinones were afforded in moderate to excellent yields in this protocol, which offers a practical and efficient access to biologically interesting 3‐alkylquinoxalin‐2(1 H )‐one derivatives. Abstract : A direct C–H alkylation of quinoxalinones at the C‐3 position with sodium alkylsulfinates and phenyliodine(III) dicarboxylates has been developed under catalyst‐free conditions. A series of 3‐alkylquinoxalinones were afforded in moderate to excellent yields in this protocol, which offers a practical and efficient access to biologically interesting 3‐alkylquinoxalin‐2(1 H )‐one derivatives.