Hollow Mesoporous Manganese Oxides: Application in Cancer Diagnosis and Therapy. Issue 15 (18th January 2022)

• Record Type: Journal Article
• Authors: Xu, Wenjing; Qing, Xin; Liu, Shengli; Yang, Dongliang; Dong, Xiaochen; Zhang, Yewei
• Is Part Of: Small. Volume 18:Issue 15(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-01-18
• Subjects: cancer treatment -- combination therapy -- drug delivery -- hollow mesoporous manganese oxides -- multimodal diagnosis; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202106511
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: The precision, minimal invasiveness, and integration of diagnosis and treatment are critical factors for tumor treatment at the present. Although nanomedicine has shown the potential in tumor precision treatment, nanocarriers with high efficiency, excellent targeting, controlled release, and good biocompatibility still need to be further explored. Hollow mesoporous manganese oxides nanomaterials (HM‐MONs), as an efficient drug delivery carrier, have attracted substantial attention in applications of tumor diagnosis and therapy due to their unique properties, such as tumor microenvironment stimuli‐responsiveness, prominent catalytic activity, excellent biodegradation, and outstanding magnetic resonance imaging ability. The HM‐MONs can not only enhance the therapeutic efficiency but also realize multimodal diagnosis of tumors. Consequently, it is necessary to introduce applications based on HM‐MONs in cancer diagnosis and therapy. In this review, the representative progress of HM‐MONs in synthesis is discussed. Then, several promising applications in drug delivery, bio‐imaging, and bio‐detection are highlighted. Finally, the challenges and perspectives of the anticancer applications are summarized, which is expected to provide meaningful guidance on further research. Abstract : This review presents the preparation methods and anticancer applications of hollow mesoporous manganese oxides nanomaterials (HM‐MONs). First, the representative progress of HM‐MONs in synthesis is systematically summarized. Second, the relevant promising applications in cancer diagnosis and therapy are highlighted. Finally, the challenges and perspectives in tumor theranostics of HM‐MONs are discussed.