Genetic Tests: Clinical Validity and Clinical Utility. (24th April 2014)

• Record Type: Journal Article
• Authors: Burke, Wylie
• Editors: Haines, Jonathan L.; Korf, Bruce R.; Morton, Cynthia C.; Seidman, Christine E.; Seidman, J.G.; Smith, Douglas R.
• Is Part Of: Current protocols in human genetics. Volume 81(2014)
• Page Start: 9.15.1
• Page End: 9.15.8
• Publication Date: 2014-04-24
• Subjects: clinical validity -- clinical utility -- predictive value -- penetrance; Human genetics -- Laboratory manuals; Genetic Techniques; Human genetics; Laboratory manuals; 599.935028
• DOI: 10.1002/0471142905.hg0915s81
• Languages: English
• ISSNs: 1934-8258

Abstract

Abstract: When evaluating the appropriate use of new genetic tests, clinicians and health care policymakers must consider the accuracy with which a test identifies a patient's clinical status (clinical validity) and the risks and benefits resulting from test use (clinical utility). Genetic tests in current use vary in accuracy and potential to improve health outcomes, and these test properties may be influenced by testing technology and the clinical setting in which the test is used. This unit defines clinical validity and clinical utility, provides examples, and considers the implications of these test properties for clinical practice. Curr. Protoc. Hum. Genet . 81:9.15.1‐9.15.8. © 2014 by John Wiley & Sons, Inc.