The MAM Rodent Model of Schizophrenia. Issue 1 (1st April 2013)

• Record Type: Journal Article
• Authors: Lodge, Daniel J.
• Editors: Crawley, Jacqueline N.; Gerfen, Charles R.; Rogawski, Michael A.; Sibley, David R.; Skolnick, Phil; Wray, Susan
• Is Part Of: Current protocols in neuroscience. Issue 63:Issue 1(2013)
• Page Start: 9.43.1
• Page End: 9.43.7
• Publication Date: 2013-04-01
• Subjects: methylazoxymethanol acetate -- rodent model -- schizophrenia -- amphetamine -- locomotor activity; Neurosciences -- Laboratory manuals; Neurosciences; Cytological Techniques; Histological Techniques; Nervous System -- anatomy & histology; Neurosciences; Laboratory Manual; Laboratory manuals; 612.8
• DOI: 10.1002/0471142301.ns0943s63
• Languages: English
• ISSNs: 1934-8576

Abstract

Abstract: Rodent models of human disease are essential to obtain a better understanding of disease pathology, the mechanism of action underlying conventional treatments, as well as for the generation of novel therapeutic approaches. There are a number of rodent models of schizophrenia based on either genetic manipulations, acute or sub‐chronic drug administration, or developmental disturbances. The prenatal methylazoxymethanol acetate (MAM) rodent model is a developmental disruption model gaining increased attention because it displays a number of histological, neurophysiological, and behavioral deficits analogous to those observed in schizophrenia patients. This unit describes the procedures required to safely induce the MAM phenotype in rats. In addition, we describe a simple behavioral procedure, amphetamine‐induced hyperlocomotion, which can be utilized to verify the MAM phenotype. Curr. Protoc. Neurosci . 63:9.43.1‐9.43.7. © 2013 by John Wiley & Sons, Inc.