International comparison of glycaemic control in people with type 1 diabetes: an update and extension. Issue 5 (26th December 2021)

• Record Type: Journal Article
• Authors: Prigge, Regina; McKnight, John A.; Wild, Sarah H.; Haynes, Aveni; Jones, Timothy W.; Davis, Elizabeth A.; Rami‐Merhar, Birgit; Fritsch, Maria; Prchla, Christine; Lavens, Astrid; Doggen, Kris; Chao, Suchsia; Aronson, Ronnie; Brown, Ruth; Ibfelt, Else H.; Svensson, Jannet; Young, Robert; Warner, Justin T.; Robinson, Holy; Laatikainen, Tiina; Rautiainen, Päivi; Delemer, Brigitte; Souchon, Pierre François; Diallo, Alpha M.; Holl, Reinhard W.; Schmid, Sebastian M.; Raile, Klemens; Tigas, Stelios; Bargiota, Alexandra; Zografou, Ioanna; Luk, Andrea O. Y.; Chan, Juliana C. N.; Dinneen, Sean F.; Buckley, Claire M.; Kgosidialwa, Oratile; Cherubini, Valentino; Gesuita, Rosaria; Strele, Ieva; Pildava, Santa; Veeze, Henk; Aanstoot, Henk‐Jan; Mul, Dick; Jefferies, Craig; Cooper, John G.; Løvaas, Karianne Fjeld; Battelino, Tadej; Dovc, Klemen; Bratina, Nataša; Eeg‐Olofsson, Katarina; Svensson, Ann‐Marie; Gudbjornsdottir, Soffia; Globa, Evgenia; Zelinska, Nataliya;
• Is Part Of: Diabetic medicine. Volume 39:Issue 5(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-26
• Subjects: glycaemic control -- HbA1c -- registers of people with diabetes -- type 1 diabetes; Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.14766
• Languages: English
• ISSNs: 0742-3071

Abstract

Abstract: Aims: To update and extend a previous cross‐sectional international comparison of glycaemic control in people with type 1 diabetes. Methods: Data were obtained for 520, 392 children and adults with type 1 diabetes from 17 population and five clinic‐based data sources in countries or regions between 2016 and 2020. Median HbA1c (IQR) and proportions of individuals with HbA1c < 58 mmol/mol (<7.5%), 58–74 mmol/mol (7.5–8.9%) and ≥75 mmol/mol (≥9.0%) were compared between populations for individuals aged <15, 15–24 and ≥25 years. Logistic regression was used to estimate the odds ratio (OR) of HbA1c < 58 mmol/mol (<7.5%) relative to ≥58 mmol/mol (≥7.5%), stratified and adjusted for sex, age and data source. Where possible, changes in the proportion of individuals in each HbA1c category compared to previous estimates were calculated. Results: Median HbA1c varied from 55 to 79 mmol/mol (7.2 to 9.4%) across data sources and age groups so a pooled estimate was deemed inappropriate. OR (95% CI) for HbA1c < 58 mmol/mol (<7.5%) were 0.91 (0.90–0.92) for women compared to men, 1.68 (1.65–1.71) for people aged <15 years and 0.81 (0.79–0.82) aged15–24 years compared to those aged ≥25 years. Differences between populations persisted after adjusting for sex, age and data source. In general, compared to our previous analysis, the proportion of people with an HbA1c < 58 mmol/l (<7.5%) increased and proportions of people with HbA1c ≥ 75 mmol/mol (≥9.0%) decreased. Conclusions: Glycaemic control of type 1 diabetes continues to vary substantially between age groups and data sources. While some improvement over time has been observed, glycaemic control remains sub‐optimal for most people with Type 1 diabetes.