Association between circulating oxidized low-density lipoprotein and atherosclerotic cardiovascular disease. Issue 2 (25th June 2017)

• Record Type: Journal Article
• Authors: Gao, Shen; Liu, Jing
• Is Part Of: Chronic diseases and translational medicine. Volume 3:Issue 2(2017)
• Page Start: 89
• Page End: 94
• Publication Date: 2017-06-25
• Subjects: Oxidized low density lipoprotein -- Atherosclerosis -- Cardiovascular disease -- Subclinical atherosclerosis -- Review; Chronic diseases -- Periodicals; Medicine -- Research -- Periodicals; Chronic diseases; Medicine -- Research; Chronic Disease; Translational Medical Research; Periodicals; Electronic journals; Fulltext; Internet Resources; Periodicals; Periodical; 616.044
• DOI: 10.1016/j.cdtm.2017.02.008
• Languages: English
• ISSNs: 2095-882X

Abstract

Abstract: Atherosclerosis is a chronic, progressive disease which eventually leads to coronary heart disease (CHD), ischemic stroke and other atherosclerotic cardiovascular disease (ASCVD). Numerous studies have demonstrated an atherogenic role of oxidized low-density lipoprotein (ox-LDL) in the progression of ASCVD. This article briefly reviews the atherogenic mechanism of ox-LDL, the methods of measuring ox-LDL in the circulation, effect of medical therapy and life-style modification on ox-LDL level, and the association between circulating ox-LDL and atherosclerosis, including clinical ASCVD events and subclinical atherosclerosis, in observational studies.