Comparison of maintenance effect of probiotics and aminosalicylates on ulcerative colitis: A meta-analysis of randomized controlled trials. Issue 1 (March 2016)

• Record Type: Journal Article
• Authors: Jiang, Yong; Zhang, Zhi-Guang; Qi, Feng-Xiang; Zhang, Ying; Han, Tao
• Is Part Of: Chronic diseases and translational medicine. Volume 2:Issue 1(2016)
• Page Start: 34
• Page End: 41
• Publication Date: 2016-03
• Subjects: Maintenance effect -- Probiotics -- Aminosalicylates -- Ulcerative colitis -- Meta-analysis; Chronic diseases -- Periodicals; Medicine -- Research -- Periodicals; Chronic diseases; Medicine -- Research; Chronic Disease; Translational Medical Research; Periodicals; Electronic journals; Fulltext; Internet Resources; Periodicals; Periodical; 616.044
• DOI: 10.1016/j.cdtm.2016.07.002
• Languages: English
• ISSNs: 2095-882X

Abstract

Abstract: Objective: To evaluate the maintenance effect of probiotics versus that of aminosalicylates on ulcerative colitis. Methods: MEDLINE, EMBASE, the Cochrane Controlled Trials Register, and the Chinese Biomedical Database were searched in English or Chinese. Data extracted were selected with strict criteria. Results: In six randomized controlled trials (RCTs), a total of 721 participants were enrolled and the maintenance effect of probiotics ( n = 364) versus that of aminosalicylates ( n = 357) on ulcerative colitis was investigated. No significant difference was observed between probiotics and aminosalicylate groups (relative risk ( RR ) = 1.08; 95% confidence interval ( CI ): 0.91–1.28; P = 0.40). Three RCTs compared the incidence of adverse events with probiotics versus those with aminosalicylates. No significant difference was observed in the incidence of adverse events between the two groups ( RR = 1.20; 95% CI : 0.92–1.56; P = 0.17). Conclusions: Probiotics and aminosalicylates both showed a maintenance effect on ulcerative colitis. However, more well-designed RCTs are required.