In-silico studies for targeting PPARγ for the Type II Diabetes Mellitus. (2022)
- Record Type:
- Journal Article
- Title:
- In-silico studies for targeting PPARγ for the Type II Diabetes Mellitus. (2022)
- Main Title:
- In-silico studies for targeting PPARγ for the Type II Diabetes Mellitus
- Authors:
- Reetu, Reetu
Garg, Aakriti
Roy, Kuldeep K.
Roy, Anupam
Gupta, Sreya
Malakar, Chandi C. - Abstract:
- Graphical abstract: Abstract: The virtual molecular library contains phenolic group at the intermediate stage was investigated which having a potency to treat Type 2 Diabetes Mellitus. The designed molecules have shown comparable in-silico binding affinity to marketed thiazolidinedione (TZD) class of drug toward peroxisome proliferator activated receptor-γ (PPAR-γ) protein. Interestingly, change of phenolic group with 5-hydroxy quinolone in pioglitazone has shown high structural conservation in PPAR-γ ligand binding domain (LBD) with pioglitazone having better affinity. This information might be very useful to identify novel lead compounds for further development toward Type 2 Diabetes Mellitus treatment targeting PPAR-γ.
- Is Part Of:
- Materials today. Volume 57:Part 1(2022)
- Journal:
- Materials today
- Issue:
- Volume 57:Part 1(2022)
- Issue Display:
- Volume 57, Issue 1, Part 1 (2022)
- Year:
- 2022
- Volume:
- 57
- Issue:
- 1
- Part:
- 1
- Issue Sort Value:
- 2022-0057-0001-0001
- Page Start:
- 44
- Page End:
- 48
- Publication Date:
- 2022
- Subjects:
- PPAR-γ -- Type 2 diabetes mellitus -- In-silico study -- Ligand binding domain -- Docking study
Materials science -- Congresses -- Periodicals
620.1 - Journal URLs:
- http://www.sciencedirect.com/science/journal/22147853 ↗
http://www.sciencedirect.com/ ↗ - DOI:
- 10.1016/j.matpr.2022.01.299 ↗
- Languages:
- English
- ISSNs:
- 2214-7853
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 21366.xml