Persulfidation is the mechanism underlying sulfide-signaling of autophagy. Issue 3 (4th March 2022)

• Record Type: Journal Article
• Authors: Gotor, Cecilia; Aroca, Angeles; Romero, Luis C.
• Is Part Of: Autophagy. Volume 18:Issue 3(2022)
• Page Start: 695
• Page End: 697
• Publication Date: 2022-03-04
• Subjects: Arabidopsis -- GAPDH -- hydrogen sulfide -- persulfidated cysteine -- posttranslational modification -- stress; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2021.1936357
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: In this commentary, we highlight the findings described in a recent paper regarding the mechanism of H2 S regulation of macroautophagy/autophagy in mammalian cells and discuss the similarities/divergencies with plant cells. The main outcome is that the posttranslational modification of thiol groups of cysteine residues to form persulfides is a conserved molecular mechanism.