Tumor Properties Mediate the Relationship between Peripheral Blood Monocytes and Tumor-Associated Macrophages in Breast Cancer. (28th May 2022)

• Record Type: Journal Article
• Authors: Stakheyeva, Marina; Patysheva, Marina; Kaigorodova, Evgenia; Zavyalova, Marina; Tarabanovskaya, Natalia; Choynzonov, Evgeny; Cherdyntseva, Nadezhda
• Is Part Of: Cancer investigation. Volume 40:Number 5(2022)
• Page Start: 442
• Page End: 456
• Publication Date: 2022-05-28
• Subjects: Breast cancer -- monocytes -- tumor-associated macrophages -- tumor cells; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2021.2016803
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: In cancer patients, circulating monocytes show functional alterations. Since monocytes are precursors of tumor-associated macrophages (TAMs), TAMs ensuring tumor viability are potentially replenished through the recruitment of monocytes with specific properties. We demonstrated that locoregional metastasis and circulating factors, such as CD45-EpCAM + CD44 + CD24-/low circulating tumor cells, and serum MCP-1 and HMGB1 were statistically associated with modulation of the monocyte features in breast cancer patients. The count of circulating CD45-EpCAM + cells correlated with CD68+, CD163 + monocyte in blood, and with density of CD68 + TAM in breast cancer tumors. Overall, the relationship between monocytes and TAMs is mediated by the tumor in breast cancer patients.