Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort. (28th May 2022)

• Record Type: Journal Article
• Authors: Kilsdonk, Ellen; van Dulmen-den Broeder, Eline; van Leeuwen, Flora E.; van den Heuvel-Eibrink, Marry M.; Loonen, Jacqueline J.; van der Pal, Helena J.; Bresters, Dorine; Versluys, A. B.; Pieters, Rob; Hauptmann, Michael; Jaspers, Monique W. M.; Neggers, Sebastian J. C.; Raphael, Martine F.; Tissing, Wim J. E.; Kremer, Leontine C. M.; Ronckers, Cécile M.
• Is Part Of: Cancer investigation. Volume 40:Number 5(2022)
• Page Start: 413
• Page End: 424
• Publication Date: 2022-05-28
• Subjects: Childhood cancer survivors -- late mortality; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2022.2034841
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: This multi-center cohort-study examined late mortality among 6, 165 Dutch five-year childhood cancer survivors diagnosed 1963–2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10, 000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963–1979 vs. later ( p -trend <0.001).