Comparative analysis of antifungal, antioxidant and cytotoxic activities of mycosynthesized silver nanoparticles and gold nanoparticles. (12th May 2022)

• Record Type: Journal Article
• Authors: BalaKumaran, M.D.; Ramachandran, R.; Balashanmugam, P.; Jagadeeswari, S.; Kalaichelvan, P.T.
• Is Part Of: Materials technology. Volume 37:Number 6(2022)
• Page Start: 411
• Page End: 421
• Publication Date: 2022-05-12
• Subjects: Aspergillus terreus -- silver nanoparticles -- gold nanoparticles -- antifungal activity -- antioxidant activity -- in vitro cytotoxic activity; Materials -- Periodicals; Materials science -- Periodicals; Materials -- Technological innovations -- Periodicals; 620.1105
• DOI: 10.1080/10667857.2020.1854518
• Languages: English
• ISSNs: 1066-7857

Abstract

ABSTRACT: This study aimed to compare the antifungal, antioxidant and cytotoxic activities of Aspergillus terreus mediated silver nanoparticles (AgNPs) with that of gold nanoparticles (AuNPs). AgNPs were spherical in shape with a size of 8–20 nm; whereas, AuNPs showed anisotropic morphology (10–50 nm). Interestingly, AgNPs showed excellent antifungal activity against all the plant pathogens tested; while, AuNPs did not show any inhibition. However, both these nanoparticles showed good antioxidant activities. Among six different cancer cell lines tested, AgNPs showed comparatively significant cytotoxicity against MCF-7 cells with an IC50 value of 2.90 μg/mL; whereas, AuNPs showed the maximum activity against HepG2 cells (IC50 : 25.79 μg/mL). Acridine orange-ethidium bromide (AO-EB) dual staining and nucleic acid staining (DAPI) confirmed the apoptotic phenomenon induced by nanoparticles, which was further confirmed by cell cycle analysis. Taken together, myco-derived AgNPs can be considered for potential biomedical and agricultural applications after thoroughly analysing their toxicity. GA: uf0001