Recent trends in praziquantel nanoformulations for helminthiasis treatment. (3rd April 2022)

• Record Type: Journal Article
• Authors: Mengarda, Ana C.; Iles, Bruno; F. Longo, João Paulo; de Moraes, Josué
• Is Part Of: Expert opinion on drug delivery. Volume 19:Number 4(2022)
• Page Start: 383
• Page End: 393
• Publication Date: 2022-04-03
• Subjects: Nanomedicine -- nanotechnology -- helminthiasis -- schistosomiasis -- parasitic diseases -- nanoformulation -- nanomaterials -- oral formulation -- pediatric formulation -- drug discovery; Drug delivery devices -- Periodicals; Drug delivery systems -- Periodicals; 615.605
• DOI: 10.1080/17425247.2022.2051477
• Languages: English
• ISSNs: 1742-5247

Abstract

ABSTRACT: Introduction: Infections caused by parasitic flatworms impose a considerable worldwide health burden. Recently, World Health Organization launched its roadmap for neglected diseases for the period 2021 to 2030 and oral treatment with praziquantel (PZQ) in tablet form is the main drug therapy for combating these diseases, but its use is limited by many drawbacks, including the high therapeutic dose due to the drug's low solubility and bioavailability. Among the strategies to improve PZQ performance, the use of drug nanocarriers has been cited as an interesting approach to overcome these pharmacological issues. Areas covered: This review focuses on the various types of nanomaterials (polymeric, lipidic, inorganic nanoparticles, and nanocrystals) which have been recently used to improve PZQ therapy. In addition, recent advances in PZQ nanoformulations, developed to overcome the barriers of the conventional drug are described. Expert opinion: Considering the poor rate of discovery in the anthelmintic segment observed in recent decades, the effective management of existing drugs has become essential. The application of new strategies based on nanotechnology can extend the useful life of PZQ in new and more effective formulations. Pharmaceutical nanotechnology can solve the pharmacokinetic challenges characteristic of PZQ and improve its solubility and bioavailability.