Natural source, bioactivity and synthesis of 3-Arylcoumarin derivatives. (31st December 2022)

• Record Type: Journal Article
• Authors: Zhang, Qiang; Miao, Yu-hang; Liu, Teng; Yun, Yin-ling; Sun, Xiao-ya; Yang, Tao; Sun, Jie
• Is Part Of: Journal of enzyme inhibition and medicinal chemistry. Volume 37:Number 1(2022)
• Page Start: 1023
• Page End: 1042
• Publication Date: 2022-12-31
• Subjects: Natural product sources -- 3-arylcoumarin derivatives -- bioactivity -- synthesis; Enzyme inhibitors -- Periodicals; Enzyme Inhibitors -- periodicals; Biochemistry -- periodicals; 572.7
• DOI: 10.1080/14756366.2022.2058499
• Languages: English
• ISSNs: 1475-6366

Abstract

Abstract: 3-arylcoumarins with different pharmacological properties widely exist in a variety of natural plants. The extensive research on 3-arylcoumarins was attributed to its therapeutic and relatively easy isolation. Therefore, 3-arylcoumarins can be recognised as useful structures for the design of novel compounds with potential pharmacological interest, particularly in the fields of anti-inflammatory, anti-cancer, antioxidant, Monoamine oxidase (MAO) enzyme inhibition, etc. The current review highlights the biological activities, design, and chemical synthetic methods of 3-arylcoumarins derivatives as well as their important natural product sources.