Advantages and drawbacks of dexamethasone in glioblastoma multiforme. (April 2022)

• Record Type: Journal Article
• Authors: Afshari, Amir R.; Sanati, Mehdi; Aminyavari, Samaneh; Shakeri, Farzaneh; Bibak, Bahram; Keshavarzi, Zakieh; Soukhtanloo, Mohammad; Jalili-Nik, Mohammad; Sadeghi, Mohammad Montazami; Mollazadeh, Hamid; Johnston, Thomas P.; Sahebkar, Amirhossein
• Is Part Of: Critical reviews in oncology/hematology. Volume 172(2022)
• Publication Date: 2022-04
• Subjects: Glioblastoma multiforme -- Dexamethasone -- Cerebral edema -- Inflammation -- Proliferation; Oncology -- Periodicals; Hematology -- Periodicals; 616.994
• DOI: 10.1016/j.critrevonc.2022.103625
• Languages: English
• ISSNs: 1040-8428

Abstract

Abstract: The most widespread, malignant, and deadliest type of glial tumor is glioblastoma multiforme (GBM). Despite radiation, chemotherapy, and radical surgery, the median survival of afflicted individuals is about 12 months. Unfortunately, existing therapeutic interventions are abysmal. Dexamethasone (Dex), a synthetic glucocorticoid, has been used for many years to treat brain edema and inflammation caused by GBM. Several investigations have recently shown that Dex also exerts antitumoral effects against GBM. On the other hand, more recent disputed findings have questioned the long-held dogma of Dex treatment for GBM. Unfortunately, steroids are associated with various undesirable side effects, including severe immunosuppression and metabolic changes like hyperglycemia, which may impair the survival of GBM patients. Current ideas and concerns about Dex's effects on GBM cerebral edema, cell proliferation, migration, and its clinical outcomes were investigated in this study. Highlights: Dexamethasone has been used for many years to treat brain edema and inflammation caused by GBM. Several investigations have shown that dexamethasone also exerts antitumoral effects against GBM. Unfortunately, steroids are associated with various undesirable side effects. Herein, we review pre-clinical and clinical applications of Dexamethasone in GBM.