Highly fluorescent functionalized nano-poly(para-phenylene ethynylene) by polymer modification. (6th April 2022)

• Record Type: Journal Article
• Authors: Song, Qinyong; Yue, Jiangtao; Zhao, Yingshi; Zhu, Jiatao; Lin, Yuebin; Zhang, Qiuyang; Pan, Changjiang; Liu, Sen; Yang, Zhongmei; Quan, Li; Wang, Yiqing
• Is Part Of: Polymer. Volume 245(2022)
• Publication Date: 2022-04-06
• Subjects: PPE -- Nanoparticle -- Photostability; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; 547.7
• DOI: 10.1016/j.polymer.2022.124701
• Languages: English
• ISSNs: 0032-3861

Abstract

Abstract: Highly photostable conjugated polymer based nanoprobe, poly(para-phenylene ethynylene), had been developed. Tumor targeting ligands folate modification made those nanoprobes to be easily and selectively taken up by cells. By grafting extended polyester side chain acting as the molecular insultors, the interchain energy transfer by isolation of conjugated polymer backbones was able to minimize, which led to reduction of π-π stacking, resulting in the quantum yield increased accordingly from 0.14% up to 36%. This method of polymer modification led to highly fluorescent functionalized nano-poly(para-phenylene ethynylene). Graphical abstract: Highly photostable conjugated polymer based nanoprobe, poly(para-phenylene ethynylene), had been developed. By grafting extended polyester side chain acting as the molecular insultors, the interchain energy transfer by isolation of conjugated polymer backbones was able to minimize, which led to reduction of π-π stacking. This method of polymer modification led to highly fluorescent functionalized nano-poly(para-phenylene ethynylene). Image 1 Highlights: 1. Poly(para-phenylene ethynylene) (PPEs) was developed into highly photostable conjugated polymer nanoprobe. 2. Tumor targeting ligands folate modification made PPEs nanoprobes to be easily and selectively taken up by cells. 3. By grafting polyester side chain acting as the molecular insultors, the QY of PPEs nanoprobes increased 257 times. 4. Polymer modification could improve the fluorescent properties of dyes and improve them applied in more fields.