Functionalized styrene synthesis via palladium-catalyzed CC cleavage of aryl ketones. (13th April 2022)

• Record Type: Journal Article
• Authors: Zhang, Xu; Wang, Zhen-Yu; Wang, Xing; Xu, Hui; Dai, Hui-Xiong
• Is Part Of: Tetrahedron letters. Volume 95(2022)
• Publication Date: 2022-04-13
• Subjects: Styrene -- Ligand-promoted -- CC cleavage -- Orthogonal Suzuki–Miyaura coupling; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.153721
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: We report herein the synthesis of functionalized styrenes via palladium-catalyzed Suzuki–Miyaura cross-coupling reaction between aryl ketone derivatives and potassium vinyltrifluoroborate. The employment of pyridine-oxazoline ligand was the key to the cleavage of unstrained CC bond. A variety of functional groups and biologically important moleculars were well tolerated. The orthogonal Suzuki–Miyaura coupling demonstrated the synthetic practicability.