NMDA and AMPA receptor physiology and role in visceral hypersensitivity: a review. Issue 5 (31st March 2022)

• Record Type: Journal Article
• Authors: Cheng, Fangli; Du, Lijun; Kim, John J.; Zhu, Feng; He, Huiqin; Dai, Ning
• Is Part Of: European journal of gastroenterology & hepatology. Volume 34:Issue 5(2022)
• Page Start: 471
• Page End: 477
• Publication Date: 2022-03-31
• Subjects: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors -- functional gastrointestinal diseases -- N-methyl-d-aspartate receptors -- visceral hypersensitivity; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Digestive organs -- Diseases; Liver -- Diseases; Periodicals; 616.33
• DOI: 10.1097/MEG.0000000000002351
• Languages: English
• ISSNs: 0954-691X

Abstract

Abstract : N -methyl-d -aspartate receptors (NMDARs) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) are excitatory neurotransmission receptors of the central nervous system and play vital roles in synaptic plasticity. Although not fully elucidated, visceral hypersensitivity is one of the most well-characterized pathophysiologic abnormalities of functional gastrointestinal diseases and appears to be associated with increased synaptic plasticity. In this study, we review the updated findings on the physiology of NMDARs and AMPARs and their relation to visceral hypersensitivity, which propose directions for future research in this field with evolving importance.