PVA-AAm-AG multi-network hydrogel with high mechanical strength and cell adhesion. (28th April 2022)

• Record Type: Journal Article
• Authors: Li, Jinming; Li, Heng; Wu, Chengwei; Zhang, Wei
• Is Part Of: Polymer. Volume 247(2022)
• Publication Date: 2022-04-28
• Subjects: Hydrogel -- Polyvinyl alcohol -- Agarose -- Mechanical property; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; 547.7
• DOI: 10.1016/j.polymer.2022.124786
• Languages: English
• ISSNs: 0032-3861

Abstract

Abstract: The self-healing ability of articular cartilage is poor, and hydrogel materials are expected to be used for cartilage replacement due to their high-water content and good biocompatibility. Here, the polyvinyl alcohol-acrylamide-agarose multi-network hydrogel was proposed. The hydrogel has a compressive modulus of 1.19 MPa and a compressive strength limit of 8.87 MPa, as well as a tensile modulus of 0.63 MPa and a tensile strength limit of 1.08 MPa. The mechanical properties of hydrogel meet the requirement for cartilage replacement materials. The in vitro cell experiments indicate that the introduction of agarose improves the cell adhesion of the hydrogel, which is expected to be beneficial in the field of biomedicine. Graphical abstract: Image 1 Highlights: PVA-AAm-AG multi-network hydrogel was synthesized by one-pot method. PVA-AAm-AG hydrogel has mechanical properties similar to natural cartilage. PVA-AAm-AG hydrogel exhibits self-recoverability and reasonable fatigue resistance. PVA-AAm-AG hydrogel has improved biocompatibility.