Resting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: A review and synthesis. (April 2022)

• Record Type: Journal Article
• Authors: Sezer, Idil; Pizzagalli, Diego A.; Sacchet, Matthew D.
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 135(2022)
• Publication Date: 2022-04
• Subjects: ACC anterior cingulate cortex -- ADHD attention-deficit/hyperactivity disorder -- aINS anterior insula -- ATN attentional network -- CAMS-R Cognitive and Affective Mindfulness Scale Revised -- CEN central executive network -- dACC dorsal anterior cingulate cortex -- DAN dorsal attention network -- DCM dynamic causal modelling -- dlPFC dorsolateral prefrontal cortex -- DMN default mode network -- dmPFC dorsomedial prefrontal cortex -- FA focused attention -- FEF frontal eye field -- FFQM Five Facet Mindfulness Questionnaire -- FMI Freiburg Mindfulness Inventory -- FPN bilateral frontoparietal network -- HEP health enhancement program -- ICA independent component analysis -- IFG inferior frontal gyrus -- IL-6 Interleukin-6 -- IPL inferior parietal lobule -- IPS inferior parietal sulcus -- KIMS Kentucky Inventory of Mindfulness Skills -- MAAS Mindful Attention and Awareness Scale -- MBET mindfulness-based exposure therapy -- MBSR mindfulness-based stress reduction -- MDD major depressive disorder -- MFG middle frontal gyrus -- mPFC medial prefrontal cortex -- OM open monitoring -- PCC posterior cingulate cortex -- PCGT present-centered group therapy -- PFC prefrontal cortex -- pgACC pregenual anterior cingulate cortex -- PHLMS Philadelphia Mindfulness Scale -- PMC premotor cortex -- PTSD post-traumatic stress disorder -- rACC rostral anterior cingulate cortex -- ROI region of interest -- rsFC resting-state functional connectivity -- sgACC subgenual anterior cingulate cortex -- SMA supplementary motor area -- SMQ Southampton Mindfulness Questionnaire -- SMS State Mindfulness Scale -- SN salience network -- STG superior temporal gyrus -- TMS Toronto Mindfulness Scale -- TPJ temporoparietal junction -- VAN ventral attention network -- vlPFC ventrolateral prefrontal cortex -- vmPFC ventromedial prefrontal cortex; Mindfulness -- Meditation -- Resting-state fMRI -- Functional connectivity -- Default mode network -- Salience network -- Frontoparietal network -- Attention control -- Emotion regulation -- Self-awareness -- Posterior cingulate cortex -- Anterior cingulate cortex -- Cuneus -- MBSR; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2022.104583
• Languages: English
• ISSNs: 0149-7634

Abstract

Abstract: This review synthesizes relations between mindfulness and resting-state fMRI functional connectivity of brain networks. Mindfulness is characterized by present-moment awareness and experiential acceptance, and relies on attention control, self-awareness, and emotion regulation. We integrate studies of functional connectivity and (1) trait mindfulness and (2) mindfulness meditation interventions. Mindfulness is related to functional connectivity in the default mode (DMN), frontoparietal (FPN), and salience (SN) networks. Specifically, mindfulness-mediated functional connectivity changes include (1) increased connectivity between posterior cingulate cortex (DMN) and dorsolateral prefrontal cortex (FPN), which may relate to attention control; (2) decreased connectivity between cuneus and SN, which may relate to self-awareness; (3) increased connectivity between rostral anterior cingulate cortex region and dorsomedial prefrontal cortex (DMN) and decreased connectivity between rostral anterior cingulate cortex region and amygdala region, both of which may relate to emotion regulation; and lastly, (4) increased connectivity between dorsal anterior cingulate cortex (SN) and anterior insula (SN) which may relate to pain relief. While further study of mindfulness is needed, neural signatures of mindfulness are emerging. Highlights: Mindfulness decreases default mode network and frontoparietal network connectivity. Attention control relates to posterior cingulate and dorsolateral prefrontal cortex coupling. Self-awareness relates to decreased connectivity between cuneus and salience network. Emotional regulation aspect of mindfulness is linked to corticolimbic modulation. Pain relief relates to coupling between dorsal anterior cingulate and salience network.